enow.com Web Search

Search results

  1. Results from the WOW.Com Content Network
  2. Helicase - Wikipedia

    en.wikipedia.org/wiki/Helicase

    DNA helicases are frequently attracted to regions of DNA damage and are essential for cellular DNA replication, recombination, repair, and transcription. Chemical manipulation of their molecular processes can change the rate at which cancer cells divide, as well as, the efficiency of transactions and cellular homeostasis.

  3. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    The replication fork is a structure that forms within the long helical DNA during DNA replication. It is produced by enzymes called helicases that break the hydrogen bonds that hold the DNA strands together in a helix.

  4. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    The process of semiconservative replication for the site of DNA replication is a fork-like DNA structure, the replication fork, where the DNA helix is open, or unwound, exposing unpaired DNA nucleotides for recognition and base pairing for the incorporation of free nucleotides into double-stranded DNA. [3]

  5. Replisome - Wikipedia

    en.wikipedia.org/wiki/Replisome

    DNA is a duplex formed by two anti-parallel strands. Following Meselson-Stahl, the process of DNA replication is semi-conservative, whereby during replication the original DNA duplex is separated into two daughter strands (referred to as the leading and lagging strand templates). Each daughter strand becomes part of a new DNA duplex.

  6. Origin of replication - Wikipedia

    en.wikipedia.org/wiki/Origin_of_replication

    More than five decades ago, Jacob, Brenner, and Cuzin proposed the replicon hypothesis to explain the regulation of chromosomal DNA synthesis in E. coli. [18] The model postulates that a diffusible, trans-acting factor, a so-called initiator, interacts with a cis-acting DNA element, the replicator, to promote replication onset at a nearby origin.

  7. Molecular Structure of Nucleic Acids: A Structure for ...

    en.wikipedia.org/wiki/Molecular_Structure_of...

    DNA replication. The two base-pair complementary chains of the DNA molecule allow replication of the genetic instructions. The "specific pairing" is a key feature of the Watson and Crick model of DNA, the pairing of nucleotide subunits. [5] In DNA, the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine. The A:T ...

  8. Origin recognition complex - Wikipedia

    en.wikipedia.org/wiki/Origin_Recognition_Complex

    When Mcm2-7 is first loaded it completely encircles the DNA and helicase activity is inhibited. In S phase, the Mcm2-7 complex interacts with helicase cofactors Cdc45 and GINS to isolate a single DNA strand, unwind the origin, and begin replication down the chromosome. In order to have bidirectional replication, this process happens twice at an ...

  9. DNA re-replication - Wikipedia

    en.wikipedia.org/wiki/DNA_re-replication

    The MCM complex is the DNA helicase that opens the helix at the replication origin and unwinds the two strands as the replication forks travel along the DNA. [5] Elevated CDK activity at the end of G1 triggers the firing of the origins and the dismantling of the pre-RCs.