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Folate deficiency, also known as vitamin B 9 deficiency, is a low level of folate and derivatives in the body. [1] This may result in megaloblastic anemia in which red blood cells become abnormally large, and folate deficiency anemia is the term given for this medical condition. [3] Signs of folate deficiency are often subtle. [4]
As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high-folate diets and supplemental ...
Folate deficiency in children may develop within a month of poor dietary intake. [14] In adults, normal total body folate is between 10 and 30 mg with about half of this amount stored in the liver and the remainder in blood and body tissues. [1] In plasma, the natural folate range is 150 to 450 nM. [15] Folate was discovered between 1931 and ...
Chronic phenytoin use has been associated with decreased bone density and increased bone fractures. Phenytoin induces metabolizing enzymes in the liver. This leads to increased metabolism of vitamin D, thus decreased vitamin D levels. Vitamin D deficiency, as well as low calcium and phosphate in the blood cause decreased bone mineral density. [20]
Other common causes include diabetes, glandular fever, vitamin B12 and folate deficiency, and hypothyroidism, which is when the thyroid gland doesn’t produce enough thyroid hormone leading to ...
Another vitamin that may be linked with ED is vitamin B9, or folic acid. A study published in the Asian Journal of Andrology analyzed the folic acid levels of men with ED and found that men with ...
Serum levels above 50 μg/L are associated with side effects. In rare cases, sulfasalazine can cause severe depression in young males. It can also cause oligospermia and temporary infertility. Immune thrombocytopenia has been reported. [12] Sulfasalazine inhibits dihydropteroate synthase, and can cause folate deficiency and megaloblastic anemia.
Folic acid is a synthetic form of folate, a B vitamin found naturally in many foods. ... Low levels of iron can result in iron deficiency anemia. This means your body doesn’t have enough ...