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Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Branded version withdrawn by originator in several countries in 2007 for hepatotoxicity. Generic versions available. Still available in US market. Nialamide: 1974 UK, US Hepatotoxicity, drug intereaction. [3] Nikethamide: 1988 multiple markets CNS Stimulation. [3] Nitrefazole: 1984 Germany Hepatic and hematologic toxicity. [3] Nomifensine: 1981 ...
Drugs and other substances that have been associated with significant hepatotoxicity (liver damage). Subcategories ...
Of these, amoxicillin-clavulanate is the most common cause of drug-induced liver injury, and paracetamol toxicity the most common cause of acute liver failure in the United States and Europe. [36] Herbal remedies and dietary supplements are another important cause of hepatitis; these are the most common causes of drug-induced hepatitis in Korea ...
You already know that drinking alcohol can wreak havoc on your liver. (And if you don't, well, here are more details on those dangers.) ... (Epigallocatechin-3-gallate, one of the catechins in ...
An insulin overdose was nearly impossible to peg as a cause of death. In multiple cases, it was William Dale Archerd's choice of poison, police said. His wives kept dying mysteriously.
Plasma perhexiline concentrations as low as 0.6mg/L> are known to cause nausea and dizziness; however, perhexiline is also known to cause hepatotoxicity and peripheral neuropathy at plasma concentrations >0.6mg/L. [9] [10] The symptoms of peripheral neuropathy include weakness or sensory loss and pain in the arms, hand, legs, and feet.
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