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Microtubule and tubulin metrics [1]. Microtubules are polymers of tubulin that form part of the cytoskeleton and provide structure and shape to eukaryotic cells. Microtubules can be as long as 50 micrometres, as wide as 23 to 27 nm [2] and have an inner diameter between 11 and 15 nm. [3]
Microtubules are assembled from dimers of α- and β-tubulin. These subunits are slightly acidic, with an isoelectric point between 5.2 and 5.8. [14] Each has a molecular weight of approximately 50 kDa. [15] To form microtubules, the dimers of α- and β-tubulin bind to GTP and assemble onto the (+) ends of microtubules while in the GTP-bound ...
The interaction between microtubules and the plasma membrane provide support, shape, and stability to the cell, as well as act as tracks for transporting materials within the cell. Overall, microtubular membranes are vital components of cellular organization and function.
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In cell biology, microtubule nucleation is the event that initiates de novo formation of microtubules (MTs). These filaments of the cytoskeleton typically form through polymerization of α- and β-tubulin dimers, the basic building blocks of the microtubule, which initially interact to nucleate a seed from which the filament elongates.
Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene. [5] [6] [7]Tubulin alpha-1A chain is a type of alpha-tubulin involved in the formation of microtubules, which are structural proteins that play a role in the cytoskeletal structure.
Microtubules exist in either a stable or unstable state. The unstable form of a microtubule is often found in cells that are undergoing rapid changes such as mitosis. [ 1 ] The unstable form exists in a state of dynamic instability where the filaments grow and shrink seemingly randomly.
Microtubules are made up of tubulin protein subunits. The tubulin protein dimers of the microtubules have hydrophobic pockets that may contain delocalized π electrons . Tubulin has other, smaller non-polar regions, for example 8 tryptophans per tubulin, which contain π electron-rich indole rings distributed throughout tubulin with separations ...