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Dimenhydrinate is an over-the-counter (OTC) first-generation antihistamine indicated for the prevention and relief of nausea and vomiting from a number of causes, including motion-sickness and post-operative nausea. [2] Dimenhydrinate can also be used for Insomnia, but this is an off label use. [5]
Its effects on central H 1 receptors cause drowsiness. Diphenhydramine is a potent antimuscarinic (a competitive antagonist of muscarinic acetylcholine receptors) and, as such, at high doses can cause anticholinergic syndrome. [68]
Travelers can also turn to medications like Dramamine or Benadryl, which Adamian recommended taking 30 to 60 minutes in advance (though she noted they cause drowsiness). Those can also help ...
The most common adverse effects noted for second-generation agents include drowsiness, fatigue, headache, nausea and dry mouth. [ 4 ] Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk for cognitive decline and dementia in older people.
The evidence does not report how antihistamines affect women differently than men. [1] Different studies have reported on antihistamine use in children, with various studies finding evidence that certain antihistamines could be used by children 2 years of age, and other drugs being safer for younger or older children.
Why does Tom Cruise love this cake? In a 2021 interview with Spectrum News, Karen recounts the story of how Cruise came to order so many cakes from their family-run business. As the story goes ...
It’s been a week since a woman died in a New York City subway car, set on fire by a homeless, undocumented man. She has yet to be identified and the man charged with her murder says he doesn’t ...
Diphenhydramine reduces nausea but causes drowsiness, and the stimulant properties of 8-Chlorotheophylline help reduce that side effect. [2] Despite being classified as a xanthine stimulant, 8-chlorotheophylline can generally not produce any locomotor activity above control in mice and does not appear to cross the blood-brain barrier well.