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Stiff-person syndrome (SPS), also known as stiff-man syndrome, [1] is a rare neurological disorder of unclear cause characterized by progressive muscular rigidity and stiffness. The stiffness primarily affects the truncal muscles and is characterised by spasms , resulting in postural deformities.
Antipsychotic medications may cause neuroleptic malignant syndrome, which can cause severe muscle rigidity with rhabdomyolysis and hyperpyrexia; Neuromuscular blocking agents used in anesthesia may result in malignant hyperthermia, also associated with rhabdomyolysis; Medications that cause serotonin syndrome, such as SSRIs
Spastic hypertonia involves uncontrollable muscle spasms, stiffening or straightening out of muscles, shock-like contractions of all or part of a group of muscles, and abnormal muscle tone. It is seen in disorders such as cerebral palsy, stroke, and spinal cord injury. Rigidity is a severe state of hypertonia where muscle resistance occurs ...
Dantrolene has been used when needed to reduce muscle rigidity, and dopamine pathway medications such as bromocriptine have shown benefit. [44] Dantrolene may act centrally on thermoregulatory pathways to lower the temperature. [7] Dantrolene also inhibits calcium release from the muscle sarcoplasmic reticulum to cause muscle relaxation. [7]
This treatment helped regress the expressed symptoms quicker than the first time. By the end of the week the patient was able to return to her normal state. [11] The second patient to undergo methylperone treatment was a 63-year-old woman with presenile dementia, which caused her to experience restlessness and paranoid hallucinations.
Dyskinesia can be anything from a slight tremor of the hands to an uncontrollable movement of the upper body or lower extremities. Discoordination can also occur internally especially with the respiratory muscles and it often goes unrecognized. [3] Dyskinesia is a symptom of several medical disorders that are distinguished by their underlying ...
More aggressive treatment includes medications such as calcium channel blockers, which dilate the blood vessels, Makol notes. The drug Sildenafil, which is also the active ingredient in Viagra ...
Painful legs (or arms), moving toes (or fingers) syndrome G25.81 Sporadic restless leg syndrome: G25.82 Familial restless leg syndrome G25.83 Stiff-person syndrome: 333.91 G25.84 Ballismus (violent involuntary rapid and irregular movements) G25.85 Hemiballismus (affecting only one side of the body) G25.85 Myokymia, facial G51.4