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The risk of developing tardive dyskinesia after chronic typical antipsychotic usage varies on several factors, such as age and gender, as well as the specific antipsychotic used. The commonly reported incidence of TD among younger patients is about 5% per year. Among older patients incidence rates as high as 20% per year have been reported.
Many patients will not develop these side effects, although there is still a significant possibility of risks associated with Antipsychotic usage. The percentage of patients affected by side effects like Tardive dyskinesia is significantly high and estimated to be a 20-50% prevalence. [1] [2]
In 2005, the FDA issued a boxed warning regarding the risk of atypical antipsychotics being prescribed among elderly patients with dementia. This advisory was associated with a decrease in use of antipsychotics, especially in elderly patients with dementia. [11]
Rates in those on atypical antipsychotics are about 20%, while those on typical antipsychotics have rates of about 30%. [5] The risk of acquiring the condition is greater in older people, [3] for women, as well as patients with mood disorders and/or medical diagnoses receiving antipsychotic medications. [8]
Aside from reduced extrapyramidal symptoms, and with the clear exception of clozapine, it is unclear whether the atypical (second-generation) antipsychotics offer advantages over older, first generation antipsychotics. [3] [27] [91] Amisulpride, olanzapine, risperidone and clozapine may be more effective but are associated with greater side ...
Antipsychotics by class Generic name Brand names Chemical class ATC code Typical antipsychotics; Acepromazine: Atravet, Acezine: phenothiazine: N05AA04
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
In older people with psychosis as a result of dementia, it may increase the risk of death. [6] It is unclear if it is safe for use in pregnancy. [6] Chlorpromazine was developed in 1950 and was the first antipsychotic on the market. [7] [8] It is on the World Health Organization's List of Essential Medicines.