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  2. Metadoxine - Wikipedia

    en.wikipedia.org/wiki/Metadoxine

    In clinical studies, metadoxine has been reported to reduce the half-life of ethanol in healthy volunteers and in acutely intoxicated patients; to accelerate the metabolism of alcohol and acetaldehyde into less toxic higher ketones and to improve their urinary clearance; to restore laboratory variables such as alcohol, ammonia, γ-GT, and alanine aminotransferase; and to improve clinical ...

  3. Eflornithine - Wikipedia

    en.wikipedia.org/wiki/Eflornithine

    [3] [4] It is an ornithine decarboxylase inhibitor. [2] Common side effects when applied as a cream include rash, redness, and burning. [4] Side effects of the injectable form include bone marrow suppression, vomiting, and seizures. [5] It is unclear if it is safe to use during pregnancy or breastfeeding. [5]

  4. Ornithine - Wikipedia

    en.wikipedia.org/wiki/Ornithine

    L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen. Ornithine is recycled and, in a manner, is a catalyst. First, ammonia is converted into carbamoyl phosphate (H 2 NC(O)OPO 2−

  5. Ornithine transcarbamylase deficiency - Wikipedia

    en.wikipedia.org/wiki/Ornithine_transcarbamylase...

    Ornithine transcarbamylase deficiency also known as OTC deficiency is the most common urea cycle disorder in humans. Ornithine transcarbamylase , the defective enzyme in this disorder, is the final enzyme in the proximal portion of the urea cycle , responsible for converting carbamoyl phosphate and ornithine into citrulline .

  6. Ornithine aminotransferase deficiency - Wikipedia

    en.wikipedia.org/wiki/Ornithine_aminotransferase...

    Ornithine concentrations can be an unreliable indicator in the newborn period, thus newborn screening may not detect this condition, even if ornithine is included in the screening panel. Enzyme assays to measure the activity of ornithine aminotransferase can be performed from fibroblasts or lymphoblasts for confirmation or during the neonatal ...

  7. Ornithine transcarbamylase - Wikipedia

    en.wikipedia.org/wiki/Ornithine_transcarbamylase

    Ornithine transcarbamylase (OTC) (also called ornithine carbamoyltransferase) is an enzyme (EC 2.1.3.3) that catalyzes the reaction between carbamoyl phosphate (CP) and ornithine (Orn) to form citrulline (Cit) and phosphate (P i). There are two classes of OTC: anabolic and catabolic.

  8. Nifurtimox - Wikipedia

    en.wikipedia.org/wiki/Nifurtimox

    Common side effects include abdominal pain, headache, nausea, and weight loss. [2] There are concerns from animal studies that it may increase the risk of cancer but these concerns have not been found in human trials. [5] Nifurtimox is not recommended in pregnancy or in those with significant kidney or liver problems. [5] It is a type of ...

  9. Bachmann-Bupp syndrome - Wikipedia

    en.wikipedia.org/wiki/Bachmann-Bupp_syndrome

    After the examination the patient's dosage increased to a 750 mg/m2 dose twice a day for another three months. [6] This then increased to a 1000 mg/m2 dose twice a day. [6] Since the beginning of the treatment, the patient has fully grown hair on their scalp, eyebrows, and eyelashes. [6] No side effects have been observed.

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