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In 1680, using the corpuscular theory as a basis, French chemist Nicolas Lemery stipulated that the acidity of any substance consisted in its pointed particles, while alkalis were endowed with pores of various sizes. [7] A molecule, according to this view, consisted of corpuscles united through a geometric locking of points and pores.
Robert Sanderson Mulliken ForMemRS [1] (June 7, 1896 – October 31, 1986) was an American physical chemist, primarily responsible for the early development of molecular orbital theory, i.e. the elaboration of the molecular orbital method of computing the structure of molecules.
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The theory was extended to map chemical space with molecular assembly trees, demonstrating the application of this approach in drug discovery, [2] in particular in research of new opiate-like molecules by connecting the "assembly pool elements through the same pattern in which they were disconnected from their parent compound(s)".
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Lorenzo Romano Amedeo Carlo Avogadro, Count of Quaregna and Cerreto [1] (/ ˌ æ v ə ˈ ɡ ɑː d r oʊ /, [2] also US: / ˌ ɑː v-/, [3] [4] [5] Italian: [ameˈdɛːo avoˈɡaːdro]; 9 August 1776 – 9 July 1856) was an Italian scientist, most noted for his contribution to molecular theory now known as Avogadro's law, which states that equal volumes of gases under the same conditions of ...
Richard F. W. Bader FRSC FCIC (October 15, 1931 – January 15, 2012) was a Canadian quantum chemist, noted for his work on the Atoms in molecules theory. This theory attempts to establish a physical basis for many of the working concepts of chemistry, such as atoms in molecules and bonding, in terms of the topology of the electron density function in three-dimensional space. [1]
Thomas Bartholin (/ b ɑːr ˈ t oʊ l ɪ n, ˈ b ɑːr t əl ɪ n /; Latinized as Thomas Bartholinus; 20 October 1616 – 4 December 1680) was a Danish physician, mathematician, and theologian. He discovered the lymphatic system in humans and advanced the theory of refrigeration anesthesia , being the first to describe it scientifically.