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Statin-associated autoimmune myopathy (SAAM), also known as anti-HMGCR myopathy, is a very rare form of muscle damage caused by the immune system in people who take statin medications. [1] However, there are cases of SAAM in patients who have not taken statin medication, and this can be explained by the exposure to natural sources of statin ...
Reports of serious adverse events within JUPITER were equally distributed between the study's rosuvastatin and placebo arms. There were no significant differences between the treatment groups with respect to muscle pain, muscle weakness, hepatic function, or renal function; however, the researchers noted small but statistically significant increases in the rate of physician-reported diabetes ...
Rhabdomyolysis (shortened as rhabdo) is a condition in which damaged skeletal muscle breaks down rapidly, often due to high intensity exercise over a short period. [6] [4] [5] Symptoms may include muscle pains, weakness, vomiting, and confusion. [3] [4] There may be tea-colored urine or an irregular heartbeat.
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A 2010 published meta-analysis found for every 255 patients taking a statin for 4 years, one additional case of diabetes would occur whilst preventing 5.4 major coronary events. [27] Some drugs interact with statins in a way that increases the risk of muscle injury called myopathy, characterized by unexplained muscle weakness or pain.
Statin-induced hepatotoxicity can cause autoimmune hepatitis and an elevation in serum levels of hepatic enzymes such as alanine aminotransferase, impairing liver function. [20] Myotoxicity is commonly presented with statin-associated muscle symptoms (SAMS), which include myalgia and myositis. [21]
These drugs make it easier to get and maintain arousal by relaxing the smooth muscle in the penis, which increases penile blood flow. Our guide to the most common ED treatments explains more about ...
As with all statin drugs, it can occasionally cause myopathy, hepatotoxicity (liver damage), dermatomyositis or rhabdomyolysis. [9] This can be life-threatening if not recognised and treated in time, so any unexplained muscle pain or weakness whilst on lovastatin should be promptly mentioned to the prescribing doctor.