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Studies of individual transcripts were being performed several decades before any transcriptomics approaches were available. Libraries of silkmoth mRNA transcripts were collected and converted to complementary DNA (cDNA) for storage using reverse transcriptase in the late 1970s. [13]
The term transcriptome is a portmanteau of the words transcript and genome; it is associated with the process of transcript production during the biological process of transcription. The early stages of transcriptome annotations began with cDNA libraries published in the 1980s. Subsequently, the advent of high-throughput technology led to ...
Transcript poetry is a research method of data collection by which researchers use selected parts of transcripts and create poems that represent the original text in a new way. It is regarded as a collaborative approach to qualitative research that promotes the inclusion of the participant in the method of data collection (Burdick, M., 2011 ...
Expression is quantified to study cellular changes in response to external stimuli, differences between healthy and diseased states, and other research questions. Transcript levels are often used as a proxy for protein abundance, but these are often not equivalent due to post transcriptional events such as RNA interference and nonsense-mediated ...
Lam Research (NASDAQ: LRCX) Q4 2024 Earnings Call Jan 29, 2025, 5:00 p.m. ET. Contents: ... This article is a transcript of this conference call produced for The Motley Fool. While we strive for ...
The modifications of primary transcripts have been further studied in research seeking greater knowledge of the role and significance of these transcripts. Experimental studies based on molecular changes to primary transcripts and the processes before and after transcription have led to greater understanding of diseases involving primary ...
Jay Bradner-- Executive Vice President, Research and Development, and Chief Scientific Officer. ... This article is a transcript of this conference call produced for The Motley Fool. While we ...
Spatial transcriptomics, or spatially resolved transcriptomics, is a method that captures positional context of transcriptional activity within intact tissue. [1] The historical precursor to spatial transcriptomics is in situ hybridization, [2] where the modernized omics terminology refers to the measurement of all the mRNA in a cell rather than select RNA targets.