Search results
Results from the WOW.Com Content Network
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated macrophages , and induces inflammation by binding to its receptors on other cells. [ 6 ]
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. [2] [3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4]
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
8600 21943 Ensembl ENSG00000120659 ENSMUSG00000022015 UniProt O14788 O35235 RefSeq (mRNA) NM_003701 NM_033012 NM_011613 RefSeq (protein) NP_003692 NP_143026 NP_035743 Location (UCSC) Chr 13: 42.56 – 42.61 Mb Chr 14: 78.51 – 78.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Receptor activator of nuclear factor kappa- Β ligand (RANKL), also known as tumor necrosis factor ...
619441 Ensembl ENSG00000248871 ENSMUSG00000018752 UniProt O43508 n/a RefSeq (mRNA) NM_172089 NM_001034097 NM_001034098 NM_001159503 RefSeq (protein) NP_003800 n/a Location (UCSC) Chr 17: 7.55 – 7.56 Mb Chr 11: 69.57 – 69.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human ...
Lymphotoxin is a member of the tumor necrosis factor (TNF) superfamily of cytokines, whose members are responsible for regulating the growth and function of lymphocytes and are expressed by a wide variety of cells in the body. [1]
Lymphotoxin-alpha (LT-α) formerly known as tumor necrosis factor-beta (TNF-β) [5] [6] is a protein that in humans is encoded by the LTA gene. [ 7 ] [ 8 ] Belonging to the hematopoietic cell line, LT-α exhibits anti-proliferative activity and causes the cellular destruction of tumor cell lines. [ 7 ]