Search results
Results from the WOW.Com Content Network
Mechanism of clathrin-dependent endocytosis. Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).
Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Therefore, adaptor proteins are responsible for the recruitment of cargo molecules into a growing clathrin-coated pits. [ 2 ]
The clathrin triskelion is composed of three clathrin heavy chains interacting at their C-termini, each ~190 kDa heavy chain has a ~25 kDa light chain tightly bound to it. The three heavy chains provide the structural backbone of the clathrin lattice, and the three light chains are thought to regulate the formation and disassembly of a clathrin ...
Dynamin-dependent clathrin-independent pathways include FEME, UFE, ADBE, EGFR-NCE and IL2Rβ uptake. [10] Dynamin-independent clathrin-independent pathways include the CLIC/GEEC pathway (regulated by Graf1), [11] as well as MEND and macropinocytosis. [10] Clathrin-mediated endocytosis is the only pathway dependent on both clathrin and dynamin.
9685 216705 Ensembl ENSG00000113282 ENSMUSG00000006169 UniProt Q14677 Q99KN9 RefSeq (mRNA) NM_001195555 NM_001195556 NM_014666 NM_001045520 NM_001346760 NM_001363484 RefSeq (protein) NP_001182484 NP_001182485 NP_055481 n/a Location (UCSC) Chr 5: 157.79 – 157.86 Mb Chr 11: 45.74 – 45.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Clathrin interactor 1 (CLINT1), also known as ...
Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene. [5] [6] Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of ...
Coat proteins can also function to bind to various transmembrane receptor proteins, called cargo receptors. These receptors help select what material is endocytosed in receptor-mediated endocytosis or intracellular transport. There are three types of vesicle coats: clathrin, COPI and COPII. The various types of coat proteins help with sorting ...
Clathrin-independent carriers (CLICs) are prevalent tubulovesicular membranes responsible for non-clathrin mediated endocytic events. They appear to endocytose material into GPI-anchored protein -enriched early endosomal compartment ( GEECs ).