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Somapacitan is the first human growth hormone (hGH) therapy that adults only take once a week by injection under the skin; other FDA-approved hGH formulations for adults with growth hormone deficiency must be administered daily. [10] It contains a small non-covalent moiety that reversibly binds to serum albumin which slows down elimination. [15]
A recombinant form of HGH called somatropin is used as a prescription drug to treat children's growth disorders and adult growth hormone deficiency. In the United States, it is only available legally from pharmacies by prescription from a licensed health care provider.
At doses 20% higher than those used in GH deficiency, growth accelerates. With several years of treatment the median gain in adult height is about 5-8 cm on this dose. The gains appear to be dose-dependent. [14] It has been used successfully in toddlers with Turner syndrome, [15] as well as in older girls. [1] [2] [3] [16]
Somatrogon, sold under the brand name Ngenla, is a medication for the treatment of growth hormone deficiency. [1] [6] [8] Somatrogon is a glycosylated protein constructed from human growth hormone and a small part of human chorionic gonadotropin which is appended to both the N-terminal and C-terminal. [8]
Somatrem is a recombinant human growth hormone used for the treatment of short stature due to decreased or absent secretion of endogenous growth hormone.
The average adult should consume at least 0.35 grams of protein per pound of body weight daily to maintain their existing muscle mass and promote overall health, according to the The Academy of ...
Wegovy, a higher-dose version of semaglutide, was approved in 2021 for weight loss in people with obesity or overweight with obesity-related conditions like high blood pressure (hypertension) and ...
[9] [15] It may be appropriate in diagnosed adult-onset deficiency, where a weekly dose of approximately 25% of that given to children is given. Lower doses again are called for in the elderly to reduce the incidence of side effects and maintain age-dependent normal levels of IGF-1.