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The term "high dead space" refers to the fluid remaining within the needle and between the syringe hub and the plunger. This space can be as high as 84 micro liters in conventional syringes. [2] Conventional high dead space syringes have existed since the mass production of plastic syringes with removable needles in 1961. [3]
[2] [7] Today, pen needles are manufactured at shorter needle lengths than required for typical vial and syringe administration, which decreases the pain associated with injection. [2] They are available in multiple lengths and gauge of needle, including 3.5mm, 4mm, 5mm, and 8mm lengths, and 31 through 34 gauge. [8]
The dilution of insulin is such that 1 mL of insulin fluid has 100 standard "units" of insulin. [6] A typical insulin vial may contain 10 mL, for 1000 units. Insulin syringes are made specifically for a patient to inject themselves, and have features to assist this purpose when compared to a syringe for use by a healthcare professional:
The gauge of the needle used can range from 25 gauge to 27 gauge, while the length can vary between 1 ⁄ 2-inch to 5 ⁄ 8-inch for injections using a syringe and needle. [ 3 ] : 722 For subcutaneous injections delivered using devices such as injector pens , the needle used may be as thin as 34 gauge (commonly 30–32 gauge), and as short as 3 ...
Automatic syringes are known since the 1910s, [2] and many spring-loaded devices with needle protectors were patented in the first half of the 20th century, [3] but it was not until 1970s when they became economically feasible to mass-produce (simple syrettes were used instead before).
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