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Picamilon (also known as N-nicotinoyl-GABA, pycamilon, and pikamilon) is a drug formed by a synthetic combination of niacin and γ-aminobutyric acid (GABA). It was developed in the Soviet Union in 1969 [ 3 ] and further studied in both Russia [ 4 ] and Japan as a prodrug of GABA.
Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1]
γ-Butyrolactone (GBL) or gamma-butyrolactone is an organic compound with the formula O=CO(CH 2) 3.It is a hygroscopic, colorless, water-miscible liquid with a weak characteristic odor.
IPTBO (isopropylbicyclophosphate, also IPPO [2]) is a bicyclic phosphate convulsant. [3] It is an extremely potent GABA receptor antagonist that can cause violent convulsions in mice.
Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound.It was first isolated by the French pharmacist and chemist Pierre François Guillaume Boullay (1777–1869) in 1812. [1]
Scutellaria is a genus of flowering plants in the mint family, Lamiaceae.They are known commonly as skullcaps. [2] The generic name is derived from the Latin scutella, meaning "a small dish, tray or platter", [3] or "little dish", [4] referring to the shape of the calyx. [4]
Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia). [5] [6] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease ...
^14 The former province of Cotabato was once the largest in the Philippines. In 1966, South Cotabato was created as a separate province. On November 22, 1973, by virtue of Presidential Decree No. 341, what remained of the old Cotabato was further divided into the provinces of North Cotabato , Maguindanao , and Sultan Kudarat .