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Other designer drugs were prepared for the first time in clandestine laboratories. [4] Because the efficacy and safety of these substances have not been thoroughly evaluated in animal and human trials, the use of some of these drugs may result in unexpected side effects. [5] The development of designer drugs may be considered a subfield of drug ...
Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
A receptor activated solely by a synthetic ligand (RASSL) or designer receptor exclusively activated by designer drugs (DREADD), is a class of artificially engineered protein receptors used in the field of chemogenetics which are selectively activated by certain ligands. [1]
Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. [1] These novel psychoactive substances should not be confused with synthetic phytocannabinoids (obtained by chemical synthesis ) or synthetic endocannabinoids from which they ...
The phrase "drug design" is similar to ligand design (i.e., design of a molecule that will bind tightly to its target). [6] Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, and side effects, that first must be optimized before a ligand can become a safe and effictive drug.
Negative side effects of human consumption of this drug may include increased heart rate, dizziness, anxiety, panic, confusion, paranoia, delusions, seizure (uncommon) and nausea. The use of dipropyltryptamine has been implicated in at least one death due to seizures, [ 12 ] although details are lacking and the drug has not officially been ...
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3',4'-Methylenedioxy-α-pyrrolidinopropiophenone (MDPPP) is a stimulant designer drug. It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills. [3] It shares a similar chemical structure with α-PPP and MDPV, [4] [1] [2] and has been shown to have reinforcing effects in rats. [5]