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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity. [4] [5]
Details on the study on fat cells and weight management The study involved a comprehensive measurement of cell volume and the number of fat cells in abdominal fat in samples from 260 participants.
The science behind weight management is complex, but one of the key concepts that governs weight management is Energy Balance. [9] Energy Balance is the phrase used to describe the difference between the number of calories a person consumes and the number of calories that same person expends (a.k.a. burns) in a given time period. [9]
Inborn errors of metabolism form a large class of genetic diseases involving congenital disorders of enzyme activities. [1] The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances into others . In most of the disorders, problems arise due to accumulation of substances which are ...
Set point theory can be construed as implying weight regulation in a wide or tight range around the set point, in a symmetric or in an asymmetric manner (i.e. treating weight gain and loss either the same or differently), and may apply to regulation of body fat levels specifically (in a multi-compartment model) or to overall body weight.
A metabolic disorder is a disorder that negatively alters the body's processing and distribution of macronutrients, such as proteins, fats, and carbohydrates.Metabolic disorders can happen when abnormal chemical reactions in the body alter the normal metabolic process. [3]
The reality is that, along with other weight management tools, like medications and lifestyle changes, certain vitamins for weight loss like B12 can support a healthy weight.
Risk factors are divided into three categories; genetic, environmental and complex factors (for example overweight). Genetic risk factors are associated with the permanent changes in the base pair sequence of human genome. In the last decade, many studies have been generated data regarding genetic basis of multifactorial diseases.