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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [ 2 ] [ 3 ] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Evidence for the existence of gene–environment correlations has recently started to accrue from molecular genetic investigations. The Collaborative Studies on Genetics of Alcoholism (COGA) group has reported that a single-nucleotide polymorphism in intron 7 of the gamma-aminobutyric acid A a2 receptor (rs279871; GABRA2) was associated with alcohol dependence and marital status.
Sex, obesity, genetic factors, race and ethnicity, binge drinking [1] Alcoholic hepatitis is hepatitis ( inflammation of the liver ) due to excessive intake of alcohol . [ 2 ] Patients typically have a history of at least 10 years of heavy alcohol intake, typically 8–10 drinks per day. [ 3 ]
In this study, however, we found a clear genetic trigger for obesity,” said lead study author Dr. Mattia Frontini, British Heart Foundation senior fellow and an associate professor in cellular ...
The main problem with this idea is the timing at which the transition is presumed to have happened, and how this would then translate into the genetic predisposition to type 2 diabetes and obesity [citation needed]. For example, the decline in reproductive investment in human societies (the so-called r to K shift) has occurred far too recently ...
Alcohol abuse affects neurons in the frontal cortex that typically have a large soma, or cell body. This type of neuron is more susceptible to Alzheimer's disease and normal aging. Research is still being conducted to determine whether there is a direct link between excessive alcohol consumption and Alzheimer's disease. [8]
Pathophysiology of obesity is the study of disordered physiological processes that cause, result from, or are otherwise associated with obesity. A number of possible pathophysiological mechanisms have been identified which may contribute in the development and maintenance of obesity. [ 1 ]
High cardiorespiratory fitness could help lower a person's risk of dementia even if they are genetically predisposed to it, a recent study has found. Staying fit may lower dementia risk even in ...