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2. Levomefolic acid - Wikipedia

   en.wikipedia.org/wiki/Levomefolic_acid

   Levomefolic acid (INN, also known as L-5-MTHF, L-methylfolate and L-5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folate used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine.

3. 5-Methyltetrahydrofolate:corrinoid/iron-sulfur protein Co ...

   en.wikipedia.org/wiki/5-Methyltetrahydrofolate:...

   [Methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate This enzyme catalyses the transfer of a carbon atom and associated hydrogen atoms from the N 5 position of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein, containing a corrin ...

4. Methylenetetrahydrofolate reductase deficiency - Wikipedia

   en.wikipedia.org/wiki/Methylenetetrahydrofolate...

   A different study corroborates these results and suggests a physiological dose (800 μg) of 5-methyltetrahydrofolate can bypass MTHFR C677T and A1298C isoforms in couples with fertility problems. [16] This treatment with 5-MTHF also avoids un-metabolized folic acid syndrome, which can occur with folic acid intakes of 5 mg per day. [16]

5. Cerebral folate deficiency - Wikipedia

   en.wikipedia.org/wiki/Cerebral_folate_deficiency

   Cerebral folate deficiency is a condition in which concentrations of 5-methyltetrahydrofolate are low in the brain as measured in the cerebral spinal fluid despite being normal in the blood. [3] Symptoms typically appear at about 5 to 24 months of age.

6. Methionine synthase - Wikipedia

   en.wikipedia.org/wiki/Methionine_synthase

   In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase). [5] [6] Methionine synthase forms part of the S-adenosylmethionine (SAMe) biosynthesis and regeneration cycle, [7] and is the enzyme responsible for linking the cycle to one-carbon metabolism via the folate cycle.

7. Folate deficiency - Wikipedia

   en.wikipedia.org/wiki/Folate_deficiency

   Cerebral folate deficiency is when levels of 5-methyltetrahydrofolate are low in the brain as measured in the cerebral spinal fluid despite being normal in the blood. [22] Symptoms typically appear at about five months of age. Without treatment there may be poor muscle tone, trouble with coordination, trouble talking, and seizures. [22]