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Coenzyme F 420 is a family of coenzymes involved in redox reactions in a number of bacteria and archaea. It is derived from coenzyme F O (7,8-didemethyl-8-hydroxy-5-deazariboflavin) and differs by having a oligoglutamyl tail attached via a 2-phospho-L-lactate bridge.
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In enzymology, a coenzyme F420 hydrogenase (EC 1.12.98.1) is an enzyme that catalyzes the chemical reaction H 2 + coenzyme F 420 ⇌ {\displaystyle \rightleftharpoons } reduced coenzyme F 420 Thus, the two substrates of this enzyme are H 2 and coenzyme F420 , whereas its product is reduced coenzyme F420.
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D-glucose 6-phosphate + oxidized coenzyme F420 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420 Thus enzyme is specific for D-glucose 6-phosphate. References
In some instances, this enzyme is fused with a coenzyme F420-0:L-glutamate ligase domain, so that the coenzyme F420-1 produced by the latter is quickly ligated to coenzyme F420-2. This enzyme is also able to serially add additional γ-glutamyl groups to F420-2, producing F420-3 and so on.
F420 may refer to: Farman F.420, a French multi-role fighter class introduced in 1934; Coenzyme F420, a coenzyme involved in redox reactions in methanogens;
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