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Iodine deficiency is a lack of the trace element iodine, an essential nutrient in the diet.It may result in metabolic problems such as goiter, sometimes as an endemic goiter as well as congenital iodine deficiency syndrome due to untreated congenital hypothyroidism, which results in developmental delays and other health problems.
Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses. It is most commonly seen in older animals, [ 1 ] and is classically associated with the formation of a long, wavy coat ( hirsutism ) and chronic laminitis .
[5] [8] [19] Because iodotyrosine deiodinase is responsible for scavenging iodide, mutations in this enzyme result in iodide deficiency. [ 25 ] The resulting high blood and urine concentrations of iodotyrosine can be used as a measure for diagnosis, as the iodide is not removed from the tyrosine residues effectively. [ 26 ]
Grass is a natural source of nutrition for a horse. Equine nutrition is the feeding of horses, ponies, mules, donkeys, and other equines. Correct and balanced nutrition is a critical component of proper horse care. Horses are non-ruminant herbivores of a type known as a "hindgut fermenter." Horses have only one stomach, as do humans.
Iodine deficiency is the most common cause of primary hypothyroidism and endemic goiter worldwide. [8] [9] In areas of the world with sufficient dietary iodine, hypothyroidism is most commonly caused by the autoimmune disease Hashimoto's thyroiditis (chronic autoimmune thyroiditis). [8] [9] Hashimoto's may be associated with a goiter.
This test is easy to perform, but is less sensitive than the oral sugar test. [15] It is best used in cases where risks of laminitis make the oral sugar test potentially unsafe. [2] The oral sugar test also requires giving the horse only a single flake of hay at 10pm the night before the test.
The enzymes catalyze a reductive elimination of iodine (the different isoforms attack different thyronine positions), thereby oxidizing themselves similar to Prx, followed by a reductive recycling of the enzyme. Iodotyrosine deiodinase contributes to breakdown of thyroid hormones.
Studies indicate that iodine deficiency, either dietary or pharmacologic, can lead to breast atypia and increased incidence of malignancy in animal models, while iodine treatment can reverse dysplasia, [7] [62] [63] with elemental iodine (I 2) having been found to be more effective in reducing ductal hyperplasias and perilobular fibrosis in ...