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The first multi-tissue epigenetic clock, Horvath's epigenetic clock, was developed by Steve Horvath, a professor of human genetics and biostatistics at UCLA (Horvath 2013). [ 10 ] [ 11 ] Horvath spent over 4 years collecting publicly available Illumina DNA methylation data and identifying suitable statistical methods.
Steve Horvath is a German–American aging researcher, geneticist, and biostatistician. He is a professor at the University of California, Los Angeles known for developing the Horvath aging clock , which is a highly accurate molecular biomarker of aging , and for developing weighted correlation network analysis .
Developed a little over a decade ago by UCLA researcher Steve Horvath, PhD, epigenetic clocks use blood, skin, or saliva samples to analyze specific patterns in the DNA, called methylation marks ...
Certain factors can accelerate the epigenetic clock, including smoking, unhealthy eating, a sedentary lifestyle and "pretty much any lifestyle factor that is bad for you," Horvath said.
This clock was generated with saliva samples and was based on 3 CpGs found in 3 gene promoters (EDARADD, TOM1L1, and NPTX2). Two years later, Steve Horvath generated epigenetic clocks for 51 different tissues and cell-types using 353 CpGs. [4]
Study co-author says he ‘could hardly believe the profound epigenetic rejuvenation effects’ New compound from pig blood reverses ageing in rats, groundbreaking study claims Skip to main content
Following in the footsteps of pioneers like Steve Horvath, Gladyshev has developed the first mouse epigenetic aging clocks. These tools can measure the effects of longevity interventions and the transition from fibroblasts to iPSCs.
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