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Eukaryotic translation is the biological process by which messenger RNA is translated into proteins in eukaryotes. It consists of four phases: initiation, elongation, termination, and recapping. It consists of four phases: initiation, elongation, termination, and recapping.
The first step in initiation is formation of the pre-initiation complex, 48S PIC. The small ribosomal subunit and various eukaryotic initiation factors are recruited to the mRNA 5′ TL and to form the 48S PIC complex, which scans 5′ to 3′ along the mRNA transcript, inspecting each successive triplet for a functional start codon.
The Kozak consensus sequence (Kozak consensus or Kozak sequence) is a nucleic acid motif that functions as the protein translation initiation site in most eukaryotic mRNA transcripts. [1] Regarded as the optimum sequence for initiating translation in eukaryotes , the sequence is an integral aspect of protein regulation and overall cellular ...
Translation promotes transcription elongation and regulates transcription termination. Functional coupling between transcription and translation is caused by direct physical interactions between the ribosome and RNA polymerase ("expressome complex"), ribosome-dependent changes to nascent mRNA secondary structure which affect RNA polymerase activity (e.g. "attenuation"), and ribosome-dependent ...
13628 Ensembl ENSG00000101210 ENSMUSG00000016349 UniProt Q05639 P62631 RefSeq (mRNA) NM_001958 NM_007906 RefSeq (protein) NP_001949 NP_031932 Location (UCSC) Chr 20: 63.49 – 63.5 Mb Chr 2: 180.79 – 180.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene. Function This gene encodes an isoform of ...
"The structure of a eukaryotic protein-coding gene. Regulatory sequence controls when and where expression occurs for the protein coding region (red). Promoter and enhancer regions (yellow) regulate the transcription of the gene into a pre-mRNA which is modified to add a 5' cap and poly-A tail (grey) and remove introns.
A eukaryotic cell has a nucleus that separates the processes of transcription and translation. Eukaryotic transcription occurs within the nucleus where DNA is packaged into nucleosomes and higher order chromatin structures. The complexity of the eukaryotic genome necessitates a great variety and complexity of gene expression control.
1937 67160 Ensembl ENSG00000254772 ENSMUSG00000071644 UniProt P26641 Q9D8N0 RefSeq (mRNA) NM_001404 NM_026007 RefSeq (protein) NP_001395 NP_080283 Location (UCSC) Chr 11: 62.56 – 62.57 Mb Chr 19: 8.94 – 8.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene. Function This gene encodes a subunit of ...