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Although the exact mechanism is not completely understood, astrocytes are known to facilitate changes in blood flow [9] [10] and have long been thought to play a role in waste removal in the brain. [11] Researchers have long known that astrocytes express water channels called aquaporins. [12]
Aquaporin-4's overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. This channel can transport water up to speeds of 3E9 molecules per second. [7] It is the primary water channel protein that reconciles the homeostasis of water in the CNS. [6]
Astrocytes (green) in the context of neurons (red) in a mouse cortex cell culture 23-week-old fetal brain culture human astrocyte Astrocytes (red-yellow) among neurons (green) in the living cerebral cortex. Astrocytes are a sub-type of glial cells in the central nervous system. They are also known as astrocytic glial cells.
Cellular extensions also known as cytoplasmic protrusions and cytoplasmic processes are those structures that project from different cells, in the body, or in other organisms. Many of the extensions are cytoplasmic protrusions such as the axon and dendrite of a neuron, known also as cytoplasmic processes. Different glial cells project ...
The astrocytes of the glia limitans are responsible for separating the brain into two primary compartments. The first compartment is the immune-privileged brain and spinal cord parenchyma. This compartment contains multiple immunosuppressive cell surface proteins such as CD200 and CD95L and it allows for the release of anti-inflammatory factors.
The main role of astrocytes is to maintain brain homeostasis and neuronal metabolism. When the astrocytes become activated, they begin to respond to damage. [3] Astrocyte activation, known as astrogliosis, responds to neurological trauma, infections, degradations, epilepsy, and tumorigenesis. Each neurological insult plays a major role in ...
Due to the way it is produced, CSF has a lower chloride level than plasma, and a higher sodium level. [2] [6] CSF contains approximately 0.59% plasma proteins, or approximately 15 to 40 mg/dL, depending on sampling site. [7] In general, globular proteins and albumin are in lower concentration in ventricular CSF compared to lumbar or cisternal ...
The choroid plexus regulates the production and composition of cerebrospinal fluid (CSF), that provides the protective buoyancy for the brain. [2] [10] CSF acts as a medium for the glymphatic filtration system that facilitates the removal of metabolic waste from the brain, and the exchange of biomolecules and xenobiotics into and out of the brain.