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1,3-Dibromobenzene has been used as a starting material in the synthesis of antiviral Lufotrelvir, in human clinical trials for the treatment of COVID-19. [3] The first step is formylation of 1,3-dibromobenzene to 2,6-dibromobenzaldehyde, by lithiation with lithium diisopropylamide in THF , followed by quenching with dimethylformamide .
[108-36-1] [106-37-6] Properties Density and phase: 1.9940 g/ml, liquid 1.9523 g/ml, liquid 1.84 g/ml, solid Solubility in water: practically insoluble Other solubilities Soluble in 70 parts ethanol. Soluble in benzene, chloroform and very soluble in diethyl ether. Melting point: 7.1 °C −7.0 °C 87 °C Boiling point: 225 °C 218–220 °C ...
2,6-Dibromophenol, 1,3-Dibromo-2-hydroxybenzene 3,4-Dibromophenol, 1,2-Dibromo-4-hydroxybenzene 3,5-Dibromophenol, 1,3-Dibromo-5-hydroxybenzene Structural formula: CAS Number: 57383-80-9: 615-58-7: 28165-52-8: 608-33-3: 615-56-5: 626-41-5 PubChem: CID 34264 from PubChem: CID 12005 from PubChem: CID 34177 from PubChem: CID 11847 from PubChem ...
1,3-Dinitrobenzene is accessible by nitration of nitrobenzene. The reaction proceeds under acid catalysis using sulfuric acid. The directing effect of the nitro group of nitrobenzene leads to 93% of the product resulting from nitration at the meta-position. The ortho- and para-products occur in only 6% and 1%, respectively. [1]
Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. [2] Carbon–halogen bond strengths, or bond dissociation energies are of 115, 83.7, 72.1, and 57.6 kcal/mol for bonded to fluorine, chlorine, bromine, or iodine, respectively ...
Approximately 95% of nitrobenzene industrially produced is hydrogenated to aniline: [5] C 6 H 5 NO 2 + 3 H 2 → C 6 H 5 NH 2 + 2 H 2 O. Aniline is a precursor to urethane polymers, rubber chemicals, pesticides, dyes (particularly azo dyes), explosives, and pharmaceuticals. Most aniline is consumed in the production of methylenedianiline, a ...
If the benzene ring contains other substituents, it belongs in Category:Nitrobenzene derivatives Wikimedia Commons has media related to Nitrobenzenes . The main article for this category is Nitrobenzenes .
The upper critical solution temperature (UCST) or upper consolute temperature is the critical temperature above which the components of a mixture are miscible in all proportions. [1] The word upper indicates that the UCST is an upper bound to a temperature range of partial miscibility, or miscibility for certain compositions only.