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Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus. The peptide belongs to gonadotropin-releasing hormone family.
The strongest activator of GnRH neurons is a hormone called kisspeptin. [16] GnRH neurons also integrate information from the body through hormones like neuropeptide Y [17] and adiponectin. [18] These hormones provide the GnRH neurons with information about the body's status to help determine whether reproduction should be prioritized or ...
Gonadotropins are glycoprotein hormones secreted by gonadotropic cells of the anterior pituitary of vertebrates. [1] [2] [3] This family includes the mammalian hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), the placental/chorionic gonadotropins, human chorionic gonadotropin (hCG) and equine chorionic gonadotropin (eCG), [3] as well as at least two forms of fish ...
The gonadotropin-releasing hormones (GnRH) (gonadoliberin) [1] are a family of peptides that play a pivotal role in reproduction. The main function of GnRH is to act on the pituitary to stimulate the synthesis and secretion of luteinizing and follicle-stimulating hormones, but GnRH also acts on the brain, retina, sympathetic nervous system, gonads, and placenta in certain species.
HPG regulation in males, with the inhibin/activin system playing a similar role on GnRH-producing cells. The hypothalamus is located in the brain and secretes GnRH. [1] GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the secretory cells of the adenohypophysis. [2]
For GnRH, TRH and GHRH the increase in Ca 2+ is achieved by the releasing hormone coupling and activating G protein coupled receptors coupled to the G q alpha subunit, activating the IP3/DAG pathway to increase Ca 2+. [1] For GHRH, however, this is a minor pathway, the main one being the cAMP dependent pathway. [2]
The production of LH is regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. [3] In females, ... This section does not cite any sources.
Kisspeptin's ability to stimulate the release of GnRH and gonadotropins is the result of its effect on GnRH release at the hypothalamus. In rat hypothalamus, it was found that over three-fourths of GnRH neurons coexpress the receptor for kisspeptin, GPR54, in their RNA.