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Long-term phase: To avoid adverse effects of long-term steroids and to avoid relapse of disease, physicians can transition to a steroid-sparing agent. B-cell depleting therapy , [ 4 ] azathioprine , methotrexate , cyclophosphamide , mycophenolate , IVIG , plasma exchange , cyclosporine , and infliximab have been used.
Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
Corticosteroids are considered first-line treatment. Prednisone dosed at 1 milligram/kilogram of body weight daily is generally recommended. [3] Corticosteroid therapy alone may be reasonable in cases of mild muscular weakness. More severe cases require the use of combined methotrexate, azathioprine, or mycophenolate with corticosteroids. [3]
The most commonly used agent is methotrexate with other frequently used agents including sulfasalazine and leflunomide. [8] Leflunomide is effective when used from 6–12 months, with similar effectiveness to methotrexate when used for 2 years. [119] Sulfasalazine also appears to be most effective in the short-term treatment of rheumatoid ...
According to the Arthritis Foundation, about 1 to 3 percent of people who take methotrexate and 10 percent of people who take leflunomide experience hair loss. Fortunately, as with most drug ...
Folate supplementation is beneficial in patients being treated with long-term, low-dose methotrexate for inflammatory conditions, such as rheumatoid arthritis (RA) or psoriasis, to avoid macrocytic anemia caused by folate deficiency. Folate is often also supplemented before some high dose chemotherapy treatments in an effort to protect healthy ...
Penicillin for cats is an antibiotic medication derived from the Penicillium fungi. It falls under the beta-lactam class of antibiotics and is primarily used to treat bacterial infections. The ...
Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high-folate diets and supplemental folic acid may help reduce the toxic side-effects of low-dose methotrexate without decreasing its effectiveness.
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