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The Warburg Effect refers to cancer cells using aerobic glycolysis for cell metabolism, which results in an increased rate of glucose uptake and a preference for lactate production, despite the presence of oxygen. [8] It is still unknown why cancer cells switch their metabolism method as it is energy inefficient.
This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with ...
A modified nanoparticle with siRNA is now being researched and has been shown to effectively shut down the expression of gro-α. They are modified with FSH β which has a high selectivity for FSHR-positive ovarian cancer cells. The nanoparticles are aiding in delivery of the siRNA to the correct place, giving them a high selective toxicity. [2]
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential ...
Other potential applications of magnetic nanoparticles are brain imaging and drug delivery past the blood-brain barrier (BBB) using biodegradable magnetic iron oxide nanoparticles. The scope of this application is the treatment of central nervous system (CNS) disorders by functioning as contrast agents and drug carriers.
This therapy has shown to work best in conjunction with chemotherapeutics or other cancer therapies. [7] Although the EPR effect has been postulated to carry the nanoparticles and spread inside the cancer tissue, only a small percentage (0.7% median) of the total administered nanoparticle dose is usually able to reach a solid tumor. [8]
Gold nanoparticles that act as drug delivery systems in conjugation with chemotherapeutic drugs typically range in size from 10 to 100 nm. [ 2 ] Surface area plays a very important role in drug delivery and per mg of gold, as diameters decrease, the surface areas needed to transport drugs increase to the point where a single 1mL volume of 1.8 ...
Nanomedicine refers to the use of nanoscale materials for medical applications. In theranostics, nanomedicine offers opportunities for targeted drug delivery, imaging, and therapy. [7] Nanoparticles can be engineered to carry therapeutic payloads, imaging agents, and targeting ligands, allowing for multimodal theranostic approaches. These ...
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