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Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
Example of direct replication and conceptual replication. There are two main types of replication in statistics. First, there is a type called “exact replication” (also called "direct replication"), which involves repeating the study as closely as possible to the original to see whether the original results can be precisely reproduced. [3]
A protocol describes what types of people may participate in the trial; the schedule of tests, procedures, medications, and dosages; and the length of the study. While in a clinical trial, participants following a protocol are seen regularly by research staff to monitor their health and to determine the safety and effectiveness of their treatment.
The study also found that most Germans have positive perceptions of replication efforts: only 18% think that non-replicability shows that science cannot be trusted, while 65% think that replication research shows that science applies quality control, and 80% agree that errors and corrections are part of science.
Molecular cloning takes advantage of the fact that the chemical structure of DNA is fundamentally the same in all living organisms. Therefore, if any segment of DNA from any organism is inserted into a DNA segment containing the molecular sequences required for DNA replication, and the resulting recombinant DNA is introduced into the organism from which the replication sequences were obtained ...
After one replication, the DNA was found to have intermediate density. Since conservative replication would result in equal amounts of DNA of the higher and lower densities (but no DNA of an intermediate density), conservative replication was excluded. However, this result was consistent with both semiconservative and dispersive replication.
Replication increases the precision of an estimate, while randomization addresses the broader applicability of a sample to a population. Replication must be appropriate: replication at the experimental unit level must be considered, in addition to replication within units.
Progress of replication forks is inhibited by many factors; collision with proteins or with complexes binding strongly on DNA, deficiency of dNTPs, nicks on template DNAs and so on. If replication forks get stuck and the rest of the sequences from the stuck forks are not copied, then the daughter strands get nick nick unreplicated sites.