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In medicine and statistics, sensitivity and specificity mathematically describe the accuracy of a test that reports the presence or absence of a medical condition. If individuals who have the condition are considered "positive" and those who do not are considered "negative", then sensitivity is a measure of how well a test can identify true ...
The relationship between sensitivity and specificity, as well as the performance of the classifier, can be visualized and studied using the Receiver Operating Characteristic (ROC) curve. In theory, sensitivity and specificity are independent in the sense that it is possible to achieve 100% in both (such as in the red/blue ball example given above).
Youden's J statistic is = + = + with the two right-hand quantities being sensitivity and specificity.Thus the expanded formula is: = + + + The index was suggested by W. J. Youden in 1950 [1] as a way of summarising the performance of a diagnostic test; however, the formula was earlier published in Science by C. S. Pierce in 1884. [2]
The log diagnostic odds ratio can also be used to study the trade-off between sensitivity and specificity [5] [6] by expressing the log diagnostic odds ratio in terms of the logit of the true positive rate (sensitivity) and false positive rate (1 − specificity), and by additionally constructing a measure, :
Condition numbers can also be defined for nonlinear functions, and can be computed using calculus.The condition number varies with the point; in some cases one can use the maximum (or supremum) condition number over the domain of the function or domain of the question as an overall condition number, while in other cases the condition number at a particular point is of more interest.
They use the sensitivity and specificity of the test to determine whether a test result usefully changes the probability that a condition (such as a disease state) exists. The first description of the use of likelihood ratios for decision rules was made at a symposium on information theory in 1954. [ 1 ]
Therefore, the choice of method of sensitivity analysis is typically dictated by a number of problem constraints, settings or challenges. Some of the most common are: Computational expense: Sensitivity analysis is almost always performed by running the model a (possibly large) number of times, i.e. a sampling-based approach. [8]
Sensitivity first definition: the ratio between output and input signal, or the slope of the output versus input response curve of a transducer, microphone or sensor; Sensitivity second definition: the minimum magnitude of input signal required to produce an output signal with a specified signal-to-noise ratio of an instrument or sensor