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At high concentrations of guanidinium chloride (e.g., 6 M), proteins lose their ordered structure, and they tend to become randomly coiled, i.e. they do not contain any residual structure. However, at concentrations in the millimolar range in vivo, guanidinium chloride has been shown to "cure" prion positive yeast cells (i.e. cells exhibiting a ...
The general structure of a guanidine. Guanidines are a group of organic compounds sharing a common functional group with the general structure (R 1 R 2 N)(R 3 R 4 N)C=N−R 5. The central bond within this group is that of an imine, and the group is related structurally to amidines and ureas.
The monomeric avidin is created by treatment of immobilized native avidin with urea or guanidine HCl (6–8 M), giving it a lower dissociation K D ≈ 10 −7 M. [19] This allows elution from the avidin matrix to occur under milder, non-denaturing conditions, using low concentrations of biotin or low pH conditions. For a single high affinity ...
The order of the tendency of ions to make or break water structure is the basis of the Hofmeister series. Hofmeister discovered a series of salts that have consistent effects on the solubility of proteins and, as it was discovered later, on the stability of their secondary and tertiary structures .
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.
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Though the Bulls pushed ahead in the third quarter and jumped to a nine-point lead after a pair of Ayo Dosunmu free throws late in the period, the Cavaliers rattled off an 11-2 run to tie the game ...