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Folate in the form of folic acid is used to treat anemia caused by folate deficiency. [3] Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby. [3] [10] NTDs include anencephaly and spina bifida, among other defects.
Treatment may include dietary changes and folic acid supplements. [1] Dietary changes including eating foods high in folate such as, fruits and green leafy vegetables can help. [1] Prevention is recommended for pregnant women or those who are planning a pregnancy. [1] Folate deficiency is very rare in countries with folic acid fortification ...
Folic acid, which is the synthetic form of the vitamin folate, is critical both in pre- and peri-conception. [7] Deficiencies in folic acid may cause neural tube defects (NTDs). Women who had 0.4 mg of folic acid in their systems due to supplementing 3 months before childbirth significantly reduced the risk of NTDs. [29]
Anemias due to other deficiencies such as folic acid or vitamin B12 can also be treated with supplementation as well; dose may vary based on level of deficiency. [32] Other forms of anemias, such as inherited or acquired anemias prior to pregnancy, will require continuous management during pregnancy as well. [29]
For example, a lack of folic acid, a B vitamin, in the diet of a mother can cause cellular neural tube deformities that result in spina bifida. Congenital disorders such as a neural tube deformity can be prevented by 72% if the mother consumes 4 mg of folic acid before the conception and after twelve weeks of pregnancy. [ 70 ]
An insufficient intake of iron, Vitamin B12, and folic acid impairs the bone marrow function. The lack of iron within a person's body can also stem from ulcer bacteria. These microbes live in the digestive tract and after many years cause ulcers in the lining of the stomach or small intestine.
The founders' aim was to reduce the number of women and babies who died during pregnancy and childbirth. [citation needed] An early donation established that a deficiency in folic acid was a factor in malformed babies. [7] Pregnant women across the world now take folic acid supplements. [8]
The recommendation came from a study conducted by the British Medical Research Council (MRC) Vitamin Study Group from July 1983 to April 1991 involving 33 centers (17 of which in the UK and the remaining 16 in 6 different countries) that compared pregnancy outcomes of folic acid and other vitamins interventions with placebo. That study found a ...
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