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  2. BRAF (gene) - Wikipedia

    en.wikipedia.org/wiki/BRAF_(gene)

    High frequency of BRAF V600E mutations have been detected in ameloblastoma, a benign but locally infiltrative odontogenic neoplasm. [39] The V600E mutation may also be linked, as a single-driver mutation (a genetic 'smoking gun') to certain cases of papillary craniopharyngioma development. [40]

  3. V600E - Wikipedia

    en.wikipedia.org/wiki/V600E

    V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. [1] [2] It is a driver mutation in a proportion of certain diagnoses, including melanoma, [3] [4] hairy cell leukemia, [5] [6] papillary thyroid carcinoma, [7] [8] colorectal cancer, [9] non-small-cell lung cancer, [10] [11] Langerhans cell histiocytosis, [12] Erdheim–Chester ...

  4. Encorafenib - Wikipedia

    en.wikipedia.org/wiki/Encorafenib

    Encorafenib is indicated in combination with binimetinib, for the treatment of people with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test; [2] in combination with cetuximab, for the treatment of adults with metastatic colorectal cancer with a BRAF V600E mutation, as detected by an FDA-approved test, after prior therapy; [2] in ...

  5. COSMIC cancer database - Wikipedia

    en.wikipedia.org/wiki/COSMIC_cancer_database

    The COSMIC (Catalogue of Somatic Mutations in Cancer) database was designed to collect and display information on somatic mutations in cancer. It was launched in 2004, with data from just four genes, HRAS, KRAS2, NRAS and BRAF. [6] These four genes are known to be somatically mutated in cancer. Since its creation, the database has expanded rapidly.

  6. Langerhans cell histiocytosis - Wikipedia

    en.wikipedia.org/wiki/Langerhans_cell_histiocytosis

    An activating somatic mutation of a proto-oncogene in the Raf family, the BRAF gene, was detected in 35 of 61 (57%) LCH biopsy samples with mutations being more common in patients younger than 10 years (76%) than in patients aged 10 years and older (44%). [31] This study documented the first recurrent mutation in LCH samples.

  7. Dabrafenib - Wikipedia

    en.wikipedia.org/wiki/Dabrafenib

    Dabrafenib is indicated as a single agent for the treatment of people with unresectable or metastatic melanoma with BRAF V600E mutation. [2] Dabrafenib is indicated, in combination with trametinib, for BRAF V600E-positive unresectable or metastatic melanoma, metastatic non-small cell lung cancer, metastatic anaplastic thyroid cancer, and unresectable or metastatic solid tumors.

  8. Binimetinib - Wikipedia

    en.wikipedia.org/wiki/Binimetinib

    The FDA approved binimetinib based primarily on evidence from one clinical trial (NCT01909453) of 383 patients with BRAF V600 mutation-positive melanoma that was advanced or could not be removed by surgery. [7] The trial was conducted at 162 sites in Europe, North America, and various countries around the world. [7]

  9. Papillary thyroid cancer - Wikipedia

    en.wikipedia.org/wiki/Papillary_thyroid_cancer

    After performing a multivariate analysis, it was found that the absence of tumor capsule was the only parameter associated (P=0.0005) with BRAF V600E mutation. [5] According to recent studies, papillary cancers carrying the common V600E mutation tend to have a more aggressive long-term course.