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2. Valsartan - Wikipedia

   en.wikipedia.org/wiki/Valsartan

   Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs). It is a reasonable initial treatment for high blood pressure. [8] It is taken by mouth. [8]

3. Sacubitril/valsartan - Wikipedia

   en.wikipedia.org/wiki/Sacubitril/valsartan

   Sacubitril/valsartan can be used instead of an ACE inhibitor or an angiotensin receptor blocker in people with heart failure and a reduced left ventricular ejection fraction (LVEF), [17] [9] alongside other standard therapies (e.g. beta-blockers) for heart failure. [10] [11] [18] To investigate its use for heart failure in those with a ...

4. Discovery and development of angiotensin receptor blockers

   en.wikipedia.org/wiki/Discovery_and_development...

   Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5- carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [ 17 ] and has been a model for the continuing development of several other ARBs.

5. Angiotensin II receptor blocker - Wikipedia

   en.wikipedia.org/wiki/Angiotensin_II_receptor...

   [citation needed] More recently, they have been used for the treatment of heart failure in patients intolerant of ACE inhibitor therapy, in particular candesartan. Irbesartan and losartan have trial data showing benefit in hypertensive patients with type 2 diabetes, [citation needed] and may delay the progression of diabetic nephropathy.

6. Antihypertensive - Wikipedia

   en.wikipedia.org/wiki/Antihypertensive

   Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%, and can reduce the likelihood of dementia ...

7. List of cardiac pharmaceutical agents - Wikipedia

   en.wikipedia.org/wiki/List_of_cardiac...

   Class of antihypertensives that work by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart. [1] Benazepril; Captopril; Enalapril; Fosinopril; Lisinopril; Moexipril; Perindopril; Quinapril; Ramipril; Trandolapril

8. Losartan - Wikipedia

   en.wikipedia.org/wiki/Losartan

   Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. [47] About 4% of an oral dose is excreted unchanged in urine, and about 6% is excreted in urine as the active metabolite. [48] The terminal elimination half-lives of losartan and EXP3174 are about 1.5 to 2.5 hours and 3 to 9 hours, respectively. [49]

9. European Society of Cardiology - Wikipedia

   en.wikipedia.org/wiki/European_Society_of_Cardiology

   The European Society of Cardiology (ESC) is an independent non-profit, non-governmental professional association that works to advance the prevention, diagnosis and management of diseases of the heart and blood vessels, and improve scientific understanding of the heart and vascular system. [2]