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Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. [5] For heart failure, it is generally used with a diuretic , such as furosemide . [ 6 ]
Enalaprilat is the active metabolite of enalapril. It is the first dicarboxylate-containing ACE inhibitor and was developed partly to overcome these limitations of captopril. The thiol functional group of captopril was replaced with a carboxylic acid group, but additional modifications were required to achieve a potency similar to captopril.
The CHI Health Center Omaha is an arena and convention center in the central United States, located in the North Downtown neighborhood of Omaha, Nebraska.Operated by the Metropolitan Entertainment & Convention Authority (MECA), the 1.1-million-square-foot (100,000 m 2) facility has an 18,975-seat arena, a 194,000 sq ft (18,000 m 2) exhibition hall, and 62,000 sq ft (5,800 m 2) of meeting space.
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Amlodipine is well absorbed by the oral route with a mean oral bioavailability around 60%; the half-life of amlodipine is about 30 h to 50 h, and steady-state plasma concentrations are achieved after 7 to 8 days of daily dosing. [7] In the blood it has high plasma protein binding of 97.5%. [43]
The long pharmacokinetic half-life and persistent ACE inhibition of moexipril allows once-daily administration. [ 15 ] Moexipril is highly lipophilic , [ 2 ] and is in the same hydrophobic range as quinapril , benazepril , and ramipril . [ 15 ]
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