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In clinical trials, the rate of thyroid tumors in patients treated with liraglutide was 1.3 per 1000 patient years (4 people) compared to 1.0 per 1000 patients (1 person) in comparison groups. The sole person in the comparator group and four of the five persons in the liraglutide group had serum markers (elevated calcitonin) suggestive of pre ...
This continued for six to 12 months. Pooled data across five clinical trials showed that the average weight loss after six months on Xenical was 12.4 pounds and after a year of treatment it was 13 ...
The researchers found a 25.6% drop in people undergoing bariatric surgery in the final six months of 2023 compared with the number of surgeries people had during the same period the year before.
A 2022 review rounded up the results from the STEP (Semaglutide Treatment Effect in People with obesity) clinical trials. These trials looked at how a weekly 2.4-milligram (mg) semaglutide ...
A 2010 phase 2 trial found cetilistat significantly reduced weight and was better tolerated than orlistat. [ 34 ] SGLT2 inhibitors cause the loss of 60–100 grams (2.1–3.5 oz) glucose in the urine each day and are associated with a modest, sustained weight loss of 1.5–2 kilograms (3.3–4.4 lb) in people with type 2 diabetes.
A 2023 systematic review and meta-analysis looked into 14 trials of tirzepatide on more than 11,000 people with type 2 diabetes. It found that doses of 5 milligrams (mg), 10 milligrams and 15 ...
In drug development, serious adverse event (SAE) is defined as any untoward medical occurrence during a human drug trial that at any dose Results in death; Is life-threatening; Requires inpatient hospitalization or causes prolongation of existing hospitalization; Results in persistent or significant disability/incapacity
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