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U.S. Route 321 (US 321) is a spur of U.S. Route 21.It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini.
US 321 south of Winnsboro Mills: 1942: current SC 270 — — US 1 in Blaney: SC 213 near Blaney: 1942: 1947 SC 271 — — US 76 northwest of Westminster: SC 288 in Salem: 1942: 1971 SC 272 — — SC 185 west of Due West: SC 256 in Donalds: 1942: 1947 SC 273 — — SC 96 in Tradesville: SC 207 south of Wolf Pond Cross Roads
The entire route was in concurrency with US 15 in South Carolina. US 15 Conn. 2.140: 3.444 US 15 / US 301 southwest of Santee: SC 6 in Santee — — Unsigned US 15 Conn. 2.140: 3.444 US 301 in Summerton: US 15 in Summerton — — Unsigned US 15 Alt. — — Sumter: Society Hill: 1955: 1957 Replaced by US 401. US 15 Conn. 0.340: 0.547
South Carolina Highway 333 (SC 333) is a 3.340-mile (5.375 km) ... SC 333 is a two-lane rural highway that connects U.S. Route 321 (US 321) and US 601. It branches ...
South Carolina Highway 2 (SC 2) is a state highway in the U.S. state of South Carolina that travels 3.9 miles (6.3 km) between two portions of U.S. Route 21/U.S. Route 176/U.S. Route 321 (US 21/US 176/US 321) in Lexington County. The southern 2.4 miles (3.9 km) of the highway are known as Frink Street while the northern 1.5 miles (2.4 km) of ...
SC 909 along Lancaster Highway. SC 909 is a two-lane rural highway that traverses from U.S. Route 321 (US 321) in Lowrys to SC 9 near Richburg.The route zig-zags in northern Chester County connecting small communities, and provides access to the Chester Catawba Regional Airport.
SC 400 begins at an intersection with U.S. Route 321 (US 321) and SC 332 (Savannah Highway/Norway Road) in Norway, Orangeburg County. It travels to the east-southeast and leaves the town limits. The highway curves to the east-northeast and crosses over Deadfall Swamp, Roberts Swamp, and Twomile Swamp before entering Bolen Town. While there, it ...
US 301 enters South Carolina over the Savannah River southwest of Allendale. In Allendale, it has a short Concurrency with US 278.Additional concurrencies include US 321 in and around Ulmer, US 601 between Bamberg and Orangeburg, then US 15 and shortly afterwards Interstate 95 (I-95) in Santee, at exit 97 before all three move across Lake Marion.