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Hydroxyzine is used in the treatment of itchiness, anxiety, and nausea due to motion sickness. [8] A systematic review concluded that hydroxyzine outperforms placebo in treating generalized anxiety disorder. Insufficient data were available to compare the drug with benzodiazepines and buspirone. [13]
Meclizine is effective in inhibiting nausea, vomiting, and dizziness caused by motion sickness. [10] The drug is safe for treating nausea in pregnancy and is a first-line therapy for this use. [11] [12] Meclizine may not be strong enough for especially sickening motion stimuli, and second-line defenses should be tried in those cases. [13]
Ethyl loflazepate also produces an active metabolite which is stronger than the parent compound. [9] Ethyl loflazepate was designed to be a prodrug for descarboxyloflazepate, its active metabolite. It is the active metabolite which is responsible for most of the pharmacological effects rather than ethyl loflazepate. [10]
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Agomelatine is also approved for the treatment of generalized anxiety disorder in adults in Australia. [2] It has been found more effective than placebo in the treatment of in a number of short-term double-blind placebo-controlled studies and in long term relapse prevention.
Maprotiline is used in the treatment of depression, such as depression associated with agitation or anxiety and has similar efficacy to the antidepressant drug moclobemide. [12] This finding has also been validated by a group of general practitioners who compared the respective efficacy and tolerability of maprotiline and moclobemide .
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