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When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds:
Drugs that interact usually share three common features: they are taken orally, normally only a small amount enters systemic blood circulation, and they are metabolized by CYP3A4. [1] The effects on the CYP3A4 in the liver could, in principle, cause interactions with non-oral drugs, [citation needed] and non-CYP3A4-mediated effects also exist. [31]
Adverse effects are uncommon and include skin rashes, pruritus (itching), erythema, angioedema, breathing problems such as dyspnea and asthma, anaphylaxis (serious allergic reactions), and decrease in the number of blood cells such as thrombocytopenia, leucopenia, agranulocytosis, and pancytopenia. [2] The latter type of side effect can be ...
This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by adding missing items with reliable sources .
You might also find these foods and drinks make your side effects worse: Spicy foods. Dairy products. Salty foods. Processed foods. Acidic foods like tomatoes or citrus fruits. Alcohol. Caffeine ...
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Since the drugs make people less hungry, eating can lose its appeal. And if a person were to overeat while on the medication, they would likely experience unpleasant gastrointestinal side effects.