Ad
related to: monotopic membrane protein
Search results
Results from the WOW.Com Content Network
Membrane proteins exist in three topologies: polytopic, bitopic, and monotopic, depending on the distribution of their domains throughout the membrane. [15] The domains of polytopic proteins cross the membrane multiple times while bitopic proteins may only pass through the membrane once typically with a transmembrane helix connecting two ...
Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane and can either penetrate the membrane (transmembrane) or associate with one or the other side of a membrane (integral monotopic). Peripheral membrane proteins are transiently associated with the ...
Schematic representation of the different types of interaction between monotopic membrane proteins and the cell membrane: 1. interaction by an amphipathic α-helix parallel to the membrane plane (in-plane membrane helix) 2. interaction by a hydrophobic loop 3. interaction by a covalently bound membrane lipid (lipidation) 4. electrostatic or ...
Depending on the number of transmembrane segments, transmembrane proteins can be classified as single-pass membrane proteins, or as multipass membrane proteins. [2] Some other integral membrane proteins are called monotopic, meaning that they are also permanently attached to the membrane, but do not pass through it. [3]
Each subunit has three different structural domains: a short N-terminal epidermal growth factor domain; an α-helical membrane-binding moiety; and a C-terminal catalytic domain. PTGS (COX, which can be confused with " cytochrome oxidase ") enzymes are monotopic membrane proteins; the membrane-binding domain consists of a series of amphipathic ...
The protein's active site is composed of an FAD cofactor covalently linked by a thioether bond to the enzyme. On the si side of the FAD the sulfide reacts and donates its electrons to FAD, while the re side of FAD is connected to a disulfide bridge and donates electrons to the quinone. 2, 3 The quinone is surrounded by Phe-385 and Ile-346.
Stomatin is a 31 kDa integral membrane protein, named after the rare human haemolytic anaemia hereditary stomatocytosis. This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and ...
In eukaryotes, lanosterol synthase is an integral monotopic protein associated with the cytosolic side of the endoplasmic reticulum. [10] Some evidence suggests that the enzyme is a soluble, non-membrane bound protein in the few prokaryotes that produce it. [11]
Ad
related to: monotopic membrane protein