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A mineralocorticoid receptor antagonist (MRA or MCRA) [1] or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure .
Aldosterone stimulates Na + and water reabsorption from the gut, salivary and sweat glands in exchange for K +. Aldosterone stimulates secretion of H + via the H+/ATPase in the intercalated cells of the cortical collecting tubules; Aldosterone upregulates expression of NCC in the distal convoluted tubule chronically and its activity acutely. [18]
ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by SCNN1A, SCNN1G, and SCNN1D. [5] ENaC is expressed in epithelial cells [5] and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons ...
The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +).It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.
The inactivating mutation leads to elevated local concentrations of cortisol in the aldosterone sensitive tissues like the kidney. Cortisol at high concentrations can cross-react and activate the mineralocorticoid receptor due to the non-selectivity of the receptor, leading to aldosterone-like effects in the kidney.
What Are Today’s NYT Strands Answers, Word List for Sunday, December 15? WAXING. WANING. CRESCENT. FULL. QUARTER. GIBBOUS. LUNARPHASE (SPANGRAM) Up Next:
Charley Hull made five birdies Friday for a 4-under 66 that gave her a two-shot lead and an extra day of her offseason holiday, along with a weekend date with Nelly Korda at The Annika. Hull, who ...
20278 Ensembl ENSG00000166828 ENSMUSG00000000216 UniProt P51170 Q9WU39 RefSeq (mRNA) NM_001039 NM_011326 RefSeq (protein) NP_001030 NP_035456 Location (UCSC) Chr 16: 23.18 – 23.22 Mb Chr 7: 121.33 – 121.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The SCNN1G gene encodes for the γ subunit of the epithelial sodium channel ENaC in vertebrates. ENaC is assembled as a ...