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Reticular fibers, reticular fibres or reticulin is a type of fiber in connective tissue [1] composed of type III collagen secreted by reticular cells. [2] They are mainly composed of reticulin protein and form a network or mesh.
Reticular connective tissue resembles areolar connective tissue, but the only fibers in its matrix are reticular fibers, which form a delicate network along which fibroblasts called reticular cells lie scattered. Although reticular fibers are widely distributed in the body, reticular tissue is limited to certain sites. It forms a labyrinth-like ...
Reticular cells provide structural support, since they produce and maintain the thin networks of fibers that are a framework for most lymphoid organs. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. They are also found within tissues, such as lymph nodules.
[23]: 171 They are found in the walls of large blood vessels and in certain ligaments, particularly in the ligamenta flava. [23]: 173 In hematopoietic and lymphatic tissues, reticular fibers made by reticular cells provide the stroma—or structural support—for the parenchyma (that is, the bulk of functional substance) of the organ.
This type of connective tissue is found mostly in the reticular layer (or deep layer) of the dermis. [3] It is also in the sclera and in the deeper skin layers. Due to high portions of collagenous fibers, dense irregular connective tissue provides strength, making the skin resistant to tearing by stretching forces from different directions.
Its fibers run in random directions and are mostly collagenous, but elastic and reticular fibers are also present. Areolar tissue is highly variable in appearance. In many serous membranes , it appears as a loose arrangement of collagenous and elastic fibers, scattered cells of various types; abundant ground substance ; numerous blood vessels.
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The reticular dermis is the lower layer of the dermis, found under the papillary dermis, composed of dense irregular connective tissue featuring densely-packed collagen fibers. It is the primary location of dermal elastic fibers. [2] The reticular region is usually much thicker than the overlying papillary dermis.