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Traditionally, prostate cancer grades were described according to the Gleason Score, a system named for the pathologist who developed it in the 1960s. Dr. Donald Gleason realized that cancerous cells fall into 5 distinct patterns as they change from normal cells to tumor cells.
Based on the Gleason score, prostate cancers are often divided into 3 groups: Cancers with a Gleason score of 6 or less may be called well differentiated or low-grade. Cancers with a Gleason score of 7 may be called moderately differentiated or intermediate-grade.
Gleason scores are a grading system for prostate cancer. Medical pathologists set Gleason scores after studying tissue samples under a microscope. Gleason scores range from 6 (low-grade cancer) to 10 (high-grade cancer).
Prostate cancer staging is based on how far the cancer has spread as well as the Gleason score and PSA levels. Learn more about prostate cancer stages here.
Learn about prostate cancer biopsies and the Gleason score. Understand how biopsies are performed, the Gleason score, and how it impacts treatment decisions.
The Gleason score is a grading system for prostate cancer that rates how aggressive the disease is, which helps doctors determine your prognosis and treatment. Named after pathologist...
The diagnosis of prostate cancer is suspected when individuals have a hard enlarged prostate or nodule on physical exam as well as an elevated prostate-specific antigen (PSA) level on laboratory analysis. The diagnosis is confirmed with a biopsy and histologic assessment.
The Gleason grade scores each sample of prostate cancer cells from 3 to 5. Doctors work out an overall Gleason score by adding together the 2 most common grades. These might be written separately, for example 3 + 4 = 7. Or as an overall Gleason score of 7. This is how the Gleason score and Grade Groups match up and what it means:
According to the NCI, a Gleason score of 6 or lower, a PSA level of 10 ng/ml or less, and an early tumor stage places you in the low-risk category. Together, these factors mean that the...
The Gleason score typically ranges from 6 to 10. Scores 2 to 5 are possible but occur so rarely that they do not feature in official classifications. Doctors diagnose prostate cancer by...