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Phenobarbital was used for over 25 years as prophylaxis in the treatment of febrile seizures. [56] Although an effective treatment in preventing recurrent febrile seizures, it had no positive effect on patient outcome or risk of developing epilepsy. The treatment of simple febrile seizures with anticonvulsant prophylaxis is no longer recommended.
The earlier Young's rule [1] for calculating the correct dose of medicine for a child is similar: it states that the child dosage is equal to the adult dosage multiplied by the child's age in years, divided by the sum of 12 plus the child's age. Young's rule was named after Thomas Young (1773–1829), an English polymath, physician and ...
The term was additionally revived by Ray Blanchard to denote men who sexually prefer 15- to 19-year-olds. [1] The typical ephebophilic age range has also been given as ages 15–16. [10] Women's sexual interest in adolescents has been studied significantly less than men's sexual interest in adolescents. [10]
Dehydration tends to be more common older adults, Shapses says, and the Centers for Disease Control and Prevention (CDC) says that their water intake is "significantly lower" than other adult age ...
It was introduced in 1997 in order to broaden the existing guidelines known as Recommended Dietary Allowances (RDAs, see below). The DRI values differ from those used in nutrition labeling on food and dietary supplement products in the U.S. and Canada, which uses Reference Daily Intakes (RDIs) and Daily Values (%DV) which were based on outdated ...
When examining the cost-effectiveness of statin use in older adults, the researchers report that statins were cost-effective, with the cost per quality-adjusted life years gained below £3,502 ...
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17]