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Phenylbiguanide (PBG) is a 5-HT3 agonist used to study the role of 5-HT3 receptors in the central nervous system. [1] It has been found to trigger dopamine release in the nucleus accumbens of rats. [ 2 ]
Biguanide (/ b aɪ ˈ ɡ w ɒ n aɪ d /) is the organic compound with the formula HN(C(NH)NH 2) 2. It is a colorless solid that dissolves in water to give a highly basic solution. It is a colorless solid that dissolves in water to give a highly basic solution.
[1] [2] It was patented in July 2021 and received breakthrough therapy designation from the Food and Drug Administration (FDA) in November 2021. [1] As of November 2021, MYCO-002 is in the preclinical research for treatment of psychiatric disorders. [1] [2] The chemical structure of MYCO-002 does not yet appear to have been disclosed. [1] [2]
[2] 6-MBPB partially substituted for MDMA in animal drug discrimination tests at lower doses and fully substituted for MDMA at the highest dose, suggesting that it has entactogen-like effects. [1] [2] [4] Along with 5-MBPB, 6-MBPB was patented by Matthew Baggott and Tactogen in 2021. [5] It was first described in the scientific literature by 2022.
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BMB-201 is a serotonin 5-HT 2A and 5-HT 2C receptor agonist described as a non-hallucinogenic psychoplastogen which is under development for the treatment of depression, anxiety, pain, and other indications.
However, those acting as serotonin 5-HT 2 receptor agonists have been found to induce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. [ 2 ] These findings suggest that substituted benzothiophenes may have entactogenic and/or psychedelic effects in humans whilst lacking stimulant effects and possibly having ...
1,4-Dimethylamylamine (1,4-DMAA), also known as 1,4-dimethylpentylamine or as 5-methylhexan-2-amine, is a stimulant drug of the alkylamine family related to methylhexanamine (1,3-DMAA; geranamine). [ 1 ] [ 2 ] It is naturally present in geranium plants and has also been found in certain other plants.