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A BARD1 mutation may increase your risk for breast cancer. More research is needed for us to better understand this risk. While a BARD1 mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives have cancer.
BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. [5] [6] [7] The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and two tandem BRCT domains (residues 568-777). [8]
BARD1 (BRCA1 Associated RING Domain 1) is a Protein Coding gene. Diseases associated with BARD1 include Breast Cancer and Inherited Cancer-Predisposing Syndrome . Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange .
BARD1 is a gene that works with the BRCA1 gene to repair damaged DNA in your body. If You Carry a BARD1 Gene Mutation, What Cancers Are You at Risk For? If a woman has a change, or...
BARD1 is a potentially predisposing BC gene, however, the rarity of its mutations and an insufficient family/study size have hampered corroboration and estimation of the associated cancer risks.
Sequencing analyses revealed that potentially pathogenic BARD1 variants likely conferred a low-moderate risk to hereditary breast cancer, but this association is inconsistent. Here, we review studies of BARD1 as a cancer predisposing gene and illustrate the challenge of discovering additional cancer risk genes for hereditary breast and/or ...
Here, we review studies of BARD1 as a cancer predisposing gene and illustrate the challenge of discovering additional cancer risk genes for hereditary breast and/or ovarian cancer.
The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa protein. BARD1 displays a dual role in cancer development and progression as it acts as a tumor suppressor and an oncogene. Structurally, BARD1 has homologous domains to ...
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain.
An inherited BARD1 mutation may affect your options for breast cancer prevention, detection and treatment. FORCE is here to guide you.