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Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others. It is a form of substance-related disorder . Differing definitions of drug abuse are used in public health , medical, and criminal justice contexts.
The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
Hazard statements form part of the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). They are intended to form a set of standardized phrases about the hazards of chemical substances and mixtures that can be translated into different languages.
These agents typically include electrophilic groups that react readily with the net negative charge of DNA molecules. [20] Examples of activation-independent carcinogens include ultraviolet light, ionizing radiation and alkylating agents. [21] The time from exposure to a carcinogen to the development of cancer is known as the latency period.
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...
a signal word – either Danger or Warning – where necessary; hazard statements, indicating the nature and degree of the risks posed by the product; precautionary statements, indicating how the product should be handled to minimize risks to the user (as well as to other people and the general environment)
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Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. [1] Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity).