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Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others. It is a form of substance-related disorder . Differing definitions of drug abuse are used in public health , medical, and criminal justice contexts.
At lower, sub-anesthetic doses, it is a promising agent for treatment of pain and treatment-resistant depression. [22] As with many antidepressants, the results of a single administration wane with time. [23] Ketamine is used as a recreational drug for its hallucinogenic and dissociative effects. [24]
The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...
The etymology of the term addiction throughout history has been misunderstood and has taken on various meanings associated with the word. [195] An example is the usage of the word in the religious landscape of early modern Europe. [196] "Addiction" at the time meant "to attach" to something, giving it both positive and negative connotations.
This study rated alcohol the most harmful drug overall, and the only drug more harmful to others than to the users themselves. [217] Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational substances. Alcohol was ...
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For example, exposure to a particular toxicant at one time in the pregnancy may result in organ damage and at another time in the pregnancy could cause death of the fetus and miscarriage. There are a number of chemicals, biological agents (such as bacteria and viruses), and physical agents (such as radiation) used in a variety of workplaces ...