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Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, it is usually is short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD-deficient ...
G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
People suffering from 6PGD or G6PD deficiency (or both) are at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
The Philippines, [g] officially the Republic of the Philippines, [h] is an archipelagic country in Southeast Asia. In the western Pacific Ocean , it consists of 7,641 islands , with a total area of roughly 300,000 square kilometers, which are broadly categorized in three main geographical divisions from north to south: Luzon , Visayas , and ...
Various genetic studies on Filipinos have been performed, to analyze the population genetics of the various ethnic groups in the Philippines.. The results of a DNA study conducted by the National Geographic's "The Genographic Project", based on genetic testings of Filipino people by the National Geographic in 2008–2009, found that the Philippines is made up of around 53% Southeast Asia and ...
The first important legislation that formed the basis of the current system of national parks and protected areas in the Philippines is Act No. 648, enacted in 1903 by the Philippine Commission. This act authorized the civil governor to "reserve for civil public purposes, and from sale or settlement, any part of the public domain not ...
A map of the Philippines showing the island groups of Luzon, the Visayas, and Mindanao. As an archipelago, the Philippines comprises about 7,641 islands [1] [2] clustered into three major island groups: Luzon, the Visayas, and Mindanao. Only about 2,000 islands are inhabited, [3] and more than 5,000 are yet to be officially named. [2]
A map showing the traditional homelands of the indigenous peoples of the Philippines by province. The indigenous peoples of the Philippines are ethnolinguistic groups or subgroups that maintain partial isolation or independence throughout the colonial era, and have retained much of their traditional pre-colonial culture and practices. [1]